Svante Pääbo

Svante Pääbo
Svante Pääbo
	; Svante Pääbo at the Royal Society admissions day in July 2016;
Born	; (1955-04-20) 20 April 1955 (age 63); Stockholm, Sweden;
Nationality	; Sweden;
Alma mater	; Uppsala University;
Known for	; Paleogenetics;
Awards	; ; ; Gottfried Wilhelm Leibniz Prize (1992); ; ; Louis-Jeantet Prize for Medicine (2005); ; ; Pour le Mérite (2008); ; ; Kistler Prize (2009); ; ; Great Cross of Merit with star (2009); ; ; Gruber Prize in Genetics (2013); ; ; ForMemRS (2016); ; ; Breakthrough Prize in Life Sciences (2016); ; ; Keio Medical Science Prize (2016); ; ;
	; Scientific career;
Fields	; Genetics; Evolutionary Anthropology;
Institutions	; Max Planck Institute for Evolutionary Anthropology;
Thesis	; How the E19 protein of adenoviruses modulates the immune system (1986);
	;
Website	; www.eva.mpg.de/genetics/staff/paabo/home.html;

Svante Pääbo ([ˈsvanːteː ˈpɛːbuː]; born 20 April 1955) is a Swedish biologist specializing in evolutionary genetics. One of the founders of paleogenetics, he has worked extensively on the Neanderthal genome.^[2]^[3]^[4]^[5]^[6]^[7] Since 1997, he has been director of the Department of Genetics at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany.^[8]^[9]^[10]^[11]^[12]

Education and early life[edit]

Pääbo was born in Stockholm and grew up with his mother, Estonian chemist Karin Pääbo.^[13] His father was biochemist Sune Bergström,^[13] who shared the Nobel Prize in Physiology or Medicine with Bengt I. Samuelsson and John R. Vane in 1982.^[14] He earned his PhD from Uppsala University in 1986 for research investigating how the E19 protein of adenoviruses modulates the immune system.^[15]

Research and career[edit]

Svante Pääbo in 2014

Pääbo is known as one of the founders of paleogenetics, a discipline that uses the methods of genetics to study early humans and other ancient populations. In 1997, Pääbo and colleagues reported their successful sequencing of Neanderthal mitochondrial DNA (mtDNA), originating from a specimen found in Feldhofer grotto in the Neander valley.^[16]^[17]

In August 2002, Pääbo's department published findings about the "language gene", FOXP2,^[18] which is lacking or damaged in some individuals with language disabilities.

In 2006, Pääbo announced a plan to reconstruct the entire genome of Neanderthals. In 2007, he was named one of Time magazine's 100 most influential people of the year.^[19]

In February 2009, at the Annual Meeting of the American Association for the Advancement of Science (AAAS) in Chicago, it was announced that the Max Planck Institute for Evolutionary Anthropology had completed the first draft version of the Neanderthal genome.^[20] Over 3 billion base pairs were sequenced in collaboration with the 454 Life Sciences Corporation. This project, led by Pääbo, will shed new light on the recent evolutionary history of modern humans.^{[citation needed]}

In March 2010, Pääbo and his coworkers published a report about the DNA analysis of a finger bone found in the Denisova Cave in Siberia; the results suggest that the bone belonged to an extinct member of the genus Homo that had not yet been recognized, the Denisova hominin.^[21]

In May 2010, Pääbo and his colleagues published a draft sequence of the Neanderthal genome in the journal Science.^[22] He and his team also concluded that there was probably interbreeding between Neanderthals and Eurasian (but not Sub-Saharan African) humans.^[23] There is growing support in the scientific community for this theory of admixture between archaic and anatomically-modern humans,^[24] though some archaeologists remain skeptical about this conclusion.^[25]^{[needs update]}^{[better source needed]}

In 2014, he published the book Neanderthal Man: In Search of Lost Genomes where he in the mixed form of a memoir and popular science tells the story of the research effort to map the Neanderthal genome combined with thought on human evolution.^[14]^[26]

Awards and honours[edit]

In 1992, he received the Gottfried Wilhelm Leibniz Prize of the Deutsche Forschungsgemeinschaft, which is the highest honour awarded in German research. Pääbo was elected a member of the Royal Swedish Academy of Sciences in 2000. In October 2009 the Foundation For the Future announced that Pääbo had been awarded the 2009 Kistler Prize for his work isolating and sequencing ancient DNA, beginning in 1984 with a 2,400-year-old mummy.^[27] In June 2010 the Federation of European Biochemical Societies (FEBS) awarded him the Theodor Bücher Medal for outstanding achievements in Biochemistry and Molecular Biology.^[28] In 2013, he received Gruber Prize in Genetics for ground breaking research in evolutionary genetics.^[29] In June 2015 he was awarded the degree of DSc (honoris causa) at NUI Galway.^[30] He was elected a Foreign Member of the Royal Society in 2016,^[1] and in 2017 was awarded the Dan David Prize. In 2018 he received the Princess of Asturias Awards in the category of Scientific Research.

Personal life[edit]

According to Neanderthal Man: In Search of Lost Genomes, Pääbo is bisexual – he assumed he was gay until he met Linda Vigilant, an American primatologist whose "boyish charms" attracted him. Currently, they are married and raising a son and a daughter together in Leipzig.

References[edit]

^ ^a^b Anon (2016). "Professor Svante Paabo ForMemRS". London: Royal Society. Archived from the original on 2016-04-29. One or more of the preceding sentences incorporates text from the royalsociety.org website where: .mw-parser-output .templatequoteoverflow:hidden;margin:1em 0;padding:0 40px.mw-parser-output .templatequote .templatequoteciteline-height:1.5em;text-align:left;padding-left:1.6em;margin-top:0
“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --"Royal Society Terms, conditions and policies". Archived from the original on September 25, 2015. Retrieved 2016-03-09. CS1 maint: BOT: original-url status unknown (link)

^ Pääbo, Svante (November 1993). "Ancient DNA". Scientific American. 269 (5): 60–66.

^ Candee, Marjorie Dent; Block, Maxine; Rothe, Anna Herthe (2007). Current biography yearbook. New York: H. W. Wilson. ISBN 0-8242-1084-0.

^ Harold M. Schmeck Jr (16 April 1985). "Intact Genetic Material Extracted from an Ancient Egyptian Mummy". New York Times. (This article shows Pääbo to be the first one to extract DNA from a thousands year dead human—not Bryan Sykes who claimed to be in his books)

^ Kolbert, Elizabeth. "Sleeping with the Enemy: What happened between the Neanderthals and us?". The New Yorker. No. August 15 & 22, 2011. pp. 64–75.

^ Svante Päabo (2014) Neanderthal Man: In Search of Lost Genomes, Basic Books, ISBN 9780465020836

^ "A Neanderthal Perspective on Human Origins" (video lecture). 10 September 2014. Retrieved 2014-11-15.

^ Gitschier, J. (2008). "Imagine: An Interview with Svante Pääbo". PLOS Genetics. PLOS. 4 (3): e1000035. doi:10.1371/journal.pgen.1000035. PMC 2274957 . PMID 18369454.

^ Zagorski, N. (2006). "Profile of Svante Paabo". Proceedings of the National Academy of Sciences of the United States of America. 103 (37): 13575–13577. doi:10.1073/pnas.0606596103. PMC 1564240 . PMID 16954182.

^ Dickman, S. (1998). "Svante Pääbo: Pushing ancient DNA to the limit". Current Biology. 8 (10): R329–R330. doi:10.1016/S0960-9822(98)70212-X. PMID 9601629.

^ Shute, N. (2003). "Portrait: Svante Paabo. The human factor". U.S. News & World Report. 134 (2): 62–63. PMID 12561700.

^ "Svante Paabo at the Max Planck Institute for Evolutionary Anthropology". Archived from the original on 2011-07-19. Retrieved 2011-07-27.

^ ^a^b Kolbert, Elizabeth, Sleeping with the Enemy, The New Yorker. 15 August 2011

^ ^a^b Peter Forbes (20 February 2014) Neanderthal Man: In Search of Lost Genomes by Svante Pääbo – review

^ Pääbo, Svante (1986). How the E19 protein of adenoviruses modulates the immune system (PhD thesis). Uppsala University. ISBN 9155419216. OCLC 16668494.

^ Krings, M; Stone, A; Schmitz, Rw; Krainitzki, H; Stoneking, M; Pääbo, S (July 1997). "Neandertal DNA sequences and the origin of modern humans". Cell. 90 (1): 19–30. doi:10.1016/S0092-8674(00)80310-4. ISSN 0092-8674. PMID 9230299.

^ Rincon, Paul (11 April 2018). "How ancient DNA is transforming our view of the past". BBC. Retrieved 11 April 2018.

^ Enard, W.; Przeworski, M.; Fisher, S. E.; Lai, C. S. L.; Wiebe, V.; Kitano, T.; Monaco, A. P.; Pääbo, S. (2002). "Molecular evolution of FOXP2, a gene involved in speech and language". Nature. 418 (6900): 869–872. doi:10.1038/nature01025. PMID 12192408.

^ Venter, J. C. (2007). "Time 100 scientists & thinkers. Svante Paabo". Time. 169 (20): 116. PMID 17536326.

^ Callaway, Ewen (12 February 2009) First draft of Neanderthal genome is unveiled New Scientist, Life, Retrieved 13 February 2015

^ Krause, J.; Fu, Q.; Good, J. M.; Viola, B.; Shunkov, M. V.; Derevianko, A. P.; Pääbo, S. (2010). "The complete mitochondrial DNA genome of an unknown hominin from southern Siberia". Nature. 464 (7290): 894–897. doi:10.1038/nature08976. PMID 20336068.

^ Green, R. E.; Krause, J.; Briggs, A. W.; Maricic, T.; Stenzel, U.; Kircher, M.; Patterson, N.; Li, H.; Zhai, W.; Fritz, M. H. Y.; Hansen, N. F.; Durand, E. Y.; Malaspinas, A. S.; Jensen, J. D.; Marques-Bonet, T.; Alkan, C.; Prüfer, K.; Meyer, M.; Burbano, H. A.; Good, J. M.; Schultz, R.; Aximu-Petri, A.; Butthof, A.; Höber, B.; Höffner, B.; Siegemund, M.; Weihmann, A.; Nusbaum, C.; Lander, E. S.; Russ, C. (2010). "A Draft Sequence of the Neandertal Genome". Science. 328 (5979): 710–722. doi:10.1126/science.1188021. PMC 5100745 . PMID 20448178. .

^ Rincon, Paul (6 May 2010). "Neanderthal genes 'survive in us'". BBC. Retrieved 7 May 2010.

^ Lalueza-Fox, C; Gilbert, MTP (2011). "Paleogenomics of Archaic Hominins". Current Biology. 21 (24): R1002–R1009. doi:10.1016/j.cub.2011.11.021.

^ Wade, Nicholas (7 May 2010). "Signs of Neanderthals Mating With Humans". The New York Times. Retrieved 7 May 2010.

^ Simon Underdown (3 April 2014) Neanderthal Man: In Search of Lost Genomes, by Svante Pääbo Times Higher Education. Retrieved 1 July 2014

^ "Foundation For the Future has selected Dr. Svante Pääbo as the 2009 winner of the Kistler Prize". Archived from the original on 2011-07-26. Retrieved 2011-07-27.

^ "FEBS MEDALS: The Theodor Bücher Lecture and Medal". Archived from the original on 2011-07-26. Retrieved 2011-07-27.

^ "Gruber Genetics Prize for Svante Pääbo". MAX-PLANCK-GESELLSCHAFT. Retrieved 2013-04-06.

^ "ONE OF WORLD'S MOST INFLUENTIAL SCIENTISTS TO SPEAK AT NUI GALWAY". Retrieved 2015-06-13.

Bibliography[edit]

"Svante Paabo publications in PubMed". Retrieved 2011-07-27.

"Svante Paabo publications in Google Scholar". Retrieved 2011-07-27.

"Edge: Mapping the Neanderthal Genome - A Conversation With Svante Pääbo". Retrieved 2011-07-27.

[frs-1] Anon (2016). "Professor Svante Paabo ForMemRS". London: Royal Society. Archived from the original on 2016-04-29. One or more of the preceding sentences incorporates text from the royalsociety.org website where: .mw-parser-output .templatequoteoverflow:hidden;margin:1em 0;padding:0 40px.mw-parser-output .templatequote .templatequoteciteline-height:1.5em;text-align:left;padding-left:1.6em;margin-top:0
“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --"Royal Society Terms, conditions and policies". Archived from the original on September 25, 2015. Retrieved 2016-03-09. CS1 maint: BOT: original-url status unknown (link)

[2] Pääbo, Svante (November 1993). "Ancient DNA". Scientific American. 269 (5): 60–66.

[3] Candee, Marjorie Dent; Block, Maxine; Rothe, Anna Herthe (2007). Current biography yearbook. New York: H. W. Wilson. ISBN 0-8242-1084-0.

[4] Harold M. Schmeck Jr (16 April 1985). "Intact Genetic Material Extracted from an Ancient Egyptian Mummy". New York Times. (This article shows Pääbo to be the first one to extract DNA from a thousands year dead human—not Bryan Sykes who claimed to be in his books)

[5] Kolbert, Elizabeth. "Sleeping with the Enemy: What happened between the Neanderthals and us?". The New Yorker. No. August 15 & 22, 2011. pp. 64–75.

[6] Svante Päabo (2014) Neanderthal Man: In Search of Lost Genomes, Basic Books, ISBN 9780465020836

[7] "A Neanderthal Perspective on Human Origins" (video lecture). 10 September 2014. Retrieved 2014-11-15.

[8] Gitschier, J. (2008). "Imagine: An Interview with Svante Pääbo". PLOS Genetics. PLOS. 4 (3): e1000035. doi:10.1371/journal.pgen.1000035. PMC 2274957 . PMID 18369454.

[9] Zagorski, N. (2006). "Profile of Svante Paabo". Proceedings of the National Academy of Sciences of the United States of America. 103 (37): 13575–13577. doi:10.1073/pnas.0606596103. PMC 1564240 . PMID 16954182.

[10] Dickman, S. (1998). "Svante Pääbo: Pushing ancient DNA to the limit". Current Biology. 8 (10): R329–R330. doi:10.1016/S0960-9822(98)70212-X. PMID 9601629.

[11] Shute, N. (2003). "Portrait: Svante Paabo. The human factor". U.S. News & World Report. 134 (2): 62–63. PMID 12561700.

[12] "Svante Paabo at the Max Planck Institute for Evolutionary Anthropology". Archived from the original on 2011-07-19. Retrieved 2011-07-27.

[kolbert-13] Kolbert, Elizabeth, Sleeping with the Enemy, The New Yorker. 15 August 2011

[forbes-14] Peter Forbes (20 February 2014) Neanderthal Man: In Search of Lost Genomes by Svante Pääbo – review

[phd-15] Pääbo, Svante (1986). How the E19 protein of adenoviruses modulates the immune system (PhD thesis). Uppsala University. ISBN 9155419216. OCLC 16668494.

[16] Krings, M; Stone, A; Schmitz, Rw; Krainitzki, H; Stoneking, M; Pääbo, S (July 1997). "Neandertal DNA sequences and the origin of modern humans". Cell. 90 (1): 19–30. doi:10.1016/S0092-8674(00)80310-4. ISSN 0092-8674. PMID 9230299.

[Rincon_2018-17] Rincon, Paul (11 April 2018). "How ancient DNA is transforming our view of the past". BBC. Retrieved 11 April 2018.

[18] Enard, W.; Przeworski, M.; Fisher, S. E.; Lai, C. S. L.; Wiebe, V.; Kitano, T.; Monaco, A. P.; Pääbo, S. (2002). "Molecular evolution of FOXP2, a gene involved in speech and language". Nature. 418 (6900): 869–872. doi:10.1038/nature01025. PMID 12192408.

[19] Venter, J. C. (2007). "Time 100 scientists & thinkers. Svante Paabo". Time. 169 (20): 116. PMID 17536326.

[20] Callaway, Ewen (12 February 2009) First draft of Neanderthal genome is unveiled New Scientist, Life, Retrieved 13 February 2015

[21] Krause, J.; Fu, Q.; Good, J. M.; Viola, B.; Shunkov, M. V.; Derevianko, A. P.; Pääbo, S. (2010). "The complete mitochondrial DNA genome of an unknown hominin from southern Siberia". Nature. 464 (7290): 894–897. doi:10.1038/nature08976. PMID 20336068.

[22] Green, R. E.; Krause, J.; Briggs, A. W.; Maricic, T.; Stenzel, U.; Kircher, M.; Patterson, N.; Li, H.; Zhai, W.; Fritz, M. H. Y.; Hansen, N. F.; Durand, E. Y.; Malaspinas, A. S.; Jensen, J. D.; Marques-Bonet, T.; Alkan, C.; Prüfer, K.; Meyer, M.; Burbano, H. A.; Good, J. M.; Schultz, R.; Aximu-Petri, A.; Butthof, A.; Höber, B.; Höffner, B.; Siegemund, M.; Weihmann, A.; Nusbaum, C.; Lander, E. S.; Russ, C. (2010). "A Draft Sequence of the Neandertal Genome". Science. 328 (5979): 710–722. doi:10.1126/science.1188021. PMC 5100745 . PMID 20448178. .

[bbc05062010-23] Rincon, Paul (6 May 2010). "Neanderthal genes 'survive in us'". BBC. Retrieved 7 May 2010.

[24] Lalueza-Fox, C; Gilbert, MTP (2011). "Paleogenomics of Archaic Hominins". Current Biology. 21 (24): R1002–R1009. doi:10.1016/j.cub.2011.11.021.

[nyt05072010-25] Wade, Nicholas (7 May 2010). "Signs of Neanderthals Mating With Humans". The New York Times. Retrieved 7 May 2010.

[26] Simon Underdown (3 April 2014) Neanderthal Man: In Search of Lost Genomes, by Svante Pääbo Times Higher Education. Retrieved 1 July 2014

[27] "Foundation For the Future has selected Dr. Svante Pääbo as the 2009 winner of the Kistler Prize". Archived from the original on 2011-07-26. Retrieved 2011-07-27.

[28] "FEBS MEDALS: The Theodor Bücher Lecture and Medal". Archived from the original on 2011-07-26. Retrieved 2011-07-27.

[29] "Gruber Genetics Prize for Svante Pääbo". MAX-PLANCK-GESELLSCHAFT. Retrieved 2013-04-06.

[30] "ONE OF WORLD'S MOST INFLUENTIAL SCIENTISTS TO SPEAK AT NUI GALWAY". Retrieved 2015-06-13.

v t e Breakthrough Prize laureates
Fundamental physics	Nima Arkani-Hamed, Alan Guth, Alexei Kitaev, Maxim Kontsevich, Andrei Linde, Juan Maldacena, Nathan Seiberg, Ashoke Sen, Edward Witten (2012) Special: Stephen Hawking, Peter Jenni, Fabiola Gianotti (ATLAS), Michel Della Negra, Tejinder Virdee, Guido Tonelli, Joseph Incandela (CMS) and Lyn Evans (LHC) (2013) Alexander Polyakov (2013) Michael Green and John Henry Schwarz (2014) Saul Perlmutter and members of the Supernova Cosmology Project; Brian Schmidt, Adam Riess and members of the High-Z Supernova Team (2015) Special: Ronald Drever, Kip Thorne, Rainer Weiss and contributors to LIGO project (2016) Yifang Wang and Kam-Biu Luk and the Daya Bay team, Atsuto Suzuki and the KamLAND team, Kōichirō Nishikawa and the K2K / T2K team, Arthur B. McDonald and the Sudbury Neutrino Observatory team, Takaaki Kajita and Yōichirō Suzuki and the Super-Kamiokande team (2016) Joseph Polchinski, Andrew Strominger, Cumrun Vafa (2017) Charles L. Bennett, Gary Hinshaw, Norman Jarosik, Lyman Page Jr., David Spergel (2018) Special: Jocelyn Bell Burnell (2018)
Life sciences	Cornelia Bargmann, David Botstein, Lewis C. Cantley, Hans Clevers, Titia de Lange, Napoleone Ferrara, Eric Lander, Charles Sawyers, Robert Weinberg, Shinya Yamanaka and Bert Vogelstein (2013) James P. Allison, Mahlon DeLong, Michael N. Hall, Robert S. Langer, Richard P. Lifton and Alexander Varshavsky (2014) Alim-Louis Benabid, Charles David Allis, Victor Ambros, Gary Ruvkun, Jennifer Doudna and Emmanuelle Charpentier (2015) Edward Boyden, Karl Deisseroth, John Hardy, Helen Hobbs and Svante Pääbo (2016) Stephen J. Elledge, Harry F. Noller, Roeland Nusse, Yoshinori Ohsumi, Huda Zoghbi (2017) Joanne Chory, Peter Walter, Kazutoshi Mori, Kim Nasmyth, Don W. Cleveland (2018)
Mathematics	Simon Donaldson, Maxim Kontsevich, Jacob Lurie, Terence Tao and Richard Taylor (2015) Ian Agol (2016) Jean Bourgain (2017) Christopher Hacon, James McKernan (2018)

v t e Fellows of the Royal Society elected in 2016
Fellows	Chris Abell Jas Pal Badyal Steven Balbus Polina Bayvel Graham Bell Martin Bridson John Burrows Katharine Cashman Sarah Cleaveland James Collier Alastair Compston Brian Cox Jack Cuzick Bill David Christl Donnelly Marcus du Sautoy Jim Dunlop Artur Ekert Maria Fitzgerald Antony Galione Pratibha Gai Harry Gilbert Patrick Gill Anne Glover Neil Gow Ian Graham Richard Harvey Adrian Hayday Ramanujan Hegde David Hight Sue Ion Eugenia Kumacheva Corinne Le Quéré Mark Lemmon David Lodge Eleanor Maguire L. Mahadevan Gil McVean Russell Morris Luke O'Neill Simon Peyton Jones Jonathon Pines Jim Prosser Sriram Ramaswamy Caroline Series Ted Shepherd Alison Smith David Wales Philip Withers Paul Workman
Honorary	Adair Turner
Foreign	Robert Cava Vint Cerf Mark Davis Jennifer Doudna Gerd Faltings John Hayes Svante Pääbo Pasko Rakic Rino Rappuoli Ellen Williams

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Svante Pääbo
Svante Pääbo at the Royal Society admissions day in July 2016
Born	(1955-04-20) 20 April 1955 (age 63) Stockholm, Sweden
Nationality	Sweden
Alma mater	Uppsala University
Known for	Paleogenetics
Awards	Gottfried Wilhelm Leibniz Prize (1992) Louis-Jeantet Prize for Medicine (2005) Pour le Mérite (2008) Kistler Prize (2009) Great Cross of Merit with star (2009) Gruber Prize in Genetics (2013) ForMemRS (2016)^[1] Breakthrough Prize in Life Sciences (2016) Keio Medical Science Prize (2016)
Scientific career
Fields	Genetics Evolutionary Anthropology
Institutions	Max Planck Institute for Evolutionary Anthropology
Thesis	How the E19 protein of adenoviruses modulates the immune system (1986)

Website	www.eva.mpg.de/genetics/staff/paabo/home.html